Herpes Research Today is a free monthly online journal that collates and summarizes the latest research about Herpes, including details on herpes simplex virus (hsv), genital, oral, symptoms, treatment.

Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner.

Burgos JS, Ramirez C, Sastre I, Valdivieso F

NEURON BioPharma, Drug Discovery Unit, Edificio BIC, Armilla, Granada, Spain. jburgos@neuronbp.com

There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known to be associated with AD.

Published 16 November 2007 in Aging Cell, 6(6): 841-2.
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