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Herpes simplex virus entry mediator associates in infected cells in a complex with viral proteins gD and at least gH.

Perez-Romero P, Perez A, Capul A, Montgomery R, Fuller AO

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109-0620, USA.

We examined herpes simplex virus (HSV)-infected human HEp-2 cells or porcine cells that express herpes virus entry mediator (HVEM) for virus and receptor protein interactions. Antibody to HVEM, or its viral ligand gD, coimmunoprecipitated several similar proteins. A prominent 110-kDa protein that coprecipitated was identified as gH. The HVEM/gD/gH complex was detected with mild or stringent cell lysis conditions. It did not form in cells infected with HSV-1(KOS)Rid1 virus or with null virus lacking gD, gH, or gL. Thus, in cells a complex forms through physical associations of HVEM, gD, and at least gH.

Published 15 March 2005 in J Virol, 79(7): 4540-4.
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